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The RNA polymerase-related factor 1 complex (Paf1C) has gradually become a key transcriptional regulatory factor in eukaryotes (Francette et al., 2021)

Inflammaging refers to the low-grade, sterile chronic inflammation affecting the aged hematopoietic system and HSC function, including metabolic capacity, differentiation, and self-renewal capacity in aged organisms, leading to various diseases 11,12,14

Through a systematic review, we identified that oxidative stress played a significant role in the pathogenesis of OA, and metformin had potential antioxidative capacity in relieving various chronic inflammation-related diseases, raising the possibility of treating OA

Although, co-expression of both c-MET and HGF were detected at various events of wound closure, tissue regeneration, and embryogenesis [8]