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72 Generating ectopic PDX models is relatively simple: freshly resected brain metastases from consenting donors are partitioned into small pieces and implanted into the mammary fat pads of immunocompromised mice

This differential methylation, characterized by hypermethylation and reduced expression of Ambra1, suggests that Ambra1 plays a pivotal role in PD pathogenesis through its regulation of the mitophagy pathway, a process influenced by DNA methylation (49)