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Braidy N, Grant R, Adams S, Brew BJ, Guillemin GJ (2009) Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons

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This process is canonically driven by the stabilization of PTEN-induced kinase 1 (PINK1) on the outer membrane of depolarized mitochondria, which subsequently recruits the E3 ubiquitin ligase Parkin (56)