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As calcium-focused neuroprotective strategies have met with limited clinical success, it is imperative that alternative therapeutic targets be considered in the attempt to antagonize ischemic-mediated injury

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2.5 Statistical Analysis Thirty-two subjects (eight hepatically impaired subjects in each of the two ChildPugh classes [A and B] and 16 healthy subjects) were expected to provide 92% and 96% power to detect 1.5-fold increases in geometric means of C max and AUC in subjects with hepatic impairment compared with healthy subjects, respectively

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