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Data indicate that the global prevalence of POI among women has reached 3.5% (7), and is closely associated with infertility, preeclampsia, embryonic chromosomal abnormalities, and a range of complications, including cardiovascular disease, osteoporosis, depression, and cognitive dysfunction (1, 811)

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The energy demands of tumor cells increase rapidly, and the rates of glucose uptake and metabolism through aerobic glycolysis are much higher than those that can be achieved through oxidative phosphorylation (OXPHOS) alone [3]

In addition, Hcy induced inflammation in the mouse retina, brain, and cultured human monocytes (U837)