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Mice expressing dominant-negative N-cadherin develop phenotype similar to IBD This study possibly provided the first experimental in vivo evidence that manipulating mucosal epithelial cell-to-cell adhesion can modulate mucosal barrier properties and that it promotes inflammation

An increase in inflammatory infiltration, particularly CD3-positive lymphocytes and M1 CD68 (PG-M1)-positive macrophages, were observed in the control group, which follows the timeline of the inflammatory process

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