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Genetic sequencing is not solely a research tool for CVS but is employed on a daily basis by the Corresponding Author in the clinical management of the condition in his patients, generally involving WGS as it also includes useful information in the mtDNA sequence, genetic architecture (large rearrangements), and pharmacogenomic variants (e.g., in dosing amitriptyline)

Jagim AR, Harty PS, Barakat AR, et al

Furthermore, we acknowledge that some of the TMAO observed could be a direct consequence of the increase in TMA

2d,e), whereas empty-vector control cells were not sensitized to DNA-damaging agents by TMLHE knockdown or mildronate (Extended Data Fig