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Deep and superficial vein thrombosis, Ischaemic lower leg due to peripheral vascular disease, thromboembolism or thrombosed popliteal aneurysm Traumatic muscle and tendon injuries such as calf muscle tear and / or haematoma (gastrocnemius, soleus or plantaris most commonly) and Achilles rupture Infective causes such as cellulitis or abscess formation Soft tissue tumours Referred radicular / neuropathic pain (sciatica)

Gary Dunbar, a neuroscientist at Central Michigan University, has had to retract a paper on Alzheimers disease while in the midst of trying to replicate its findings

Purity verification: We looked for a stated HPLC purity figure backed by a chromatogram, not just a banner number

Challenges in the treatment of chronic wounds