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At the same time, to increase the efficiency of oxygen transport, the red blood cells in the blood will increase, making the blood viscosity increase, leading to a decrease in the speed of blood flow, which in turn affects the delivery of oxygen (Richalet et al., 2023)

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In the CNS, propionate protects the bloodbrain barrier (BBB) via FFAR3 on the surface of endothelial cells (210), whereas in the intestinal barrier, SCFAs, especially acetate, propionate, and butyrate, are more protective of the intestinal barrier (211)