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The clinical utility of these genetic markers remains limited, as current models do not achieve the accuracy needed for routine clinical use [85, 86, 89]

Studies show that glutathione supplementation increases plasma antioxidant capacity and reduces oxidative stress biomarkers by up to 35%, confirming its role in recycling and regeneration pathways (NIH)

In a model of A-induced neuronal injury, lycopene did not activate NF-B, p65, or TLR4 expression (Tripathi et al., 2018), but restored mitochondrial morphological membrane potential and ATP levels (Qu et al., 2016) and inhibited Bax and mitochondria

In our study, though we did not observe an obvious deacetylation of SKP2 by SIRT7, in future study, it would be interesting to evaluate whether SIRT7 also contributes to SKP2 protein stability via APC-Cdh1 E3 ubiquitin-ligase