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Description

Nrf2 is a transcription factor that regulates several enzymes involved in cellular stress responses, some of which include superoxide dismutase catalase, glutathione peroxidase, and glutathione reductase 5

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Under normal physiological conditions, Keap1, as the substrate adaptor of the E3 ubiquitin ligase complex, maintains intracellular redox balance by promoting the ubiquitination and degradation of Nrf2