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Additionally, miRNA alterations have been found as well, as it were shown decreased miR-127 and miR-146-b levels in rat mammary tissues following both acute and prolonged light-dark alterations 221

This ACC acetylates histone H3K27, promoting NFYA expression, which ultimately upregulates DLD, PKM2, and IDH1, enhancing glycolysis and proliferation of PASMCs