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Heterogeneity of human ALI/ARDS Large epidemiology studies on ALI patients found that clinical risk factors of intrapulmonary origins, such as pneumonia, lung contusion, and aspiration, etc., account for the majority of ALI causes (up to ~ 80%), while those of extrapulmonary origin, such as non-pulmonary sepsis and non-cardiogenic shock, account for a small portion [84]

4.4 Inducing apoptosis in cancer cells Tumorigenesis is associated with uncontrolled apoptosis of tumor cells, and the search for highly efficient and low-toxic apoptosis-inducing agents with a clear mechanism of action is an important strategy for tumor prevention and treatment

Genetic aberrations in macroautophagy genes leading to diseases