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Comparative efficacy and tolerability of antidepressants for acute bipolar depression in adults In the above-mentioned systematic review and network meta-analysis [7], antidepressants seemed to be an efficacious drug class but were associated with a higher risk for manic switch than antipsychotics [7]

If the committee recommends inclusion, the FDA would still need to complete its review and rulemaking process before formally adding any of the substances to the 503A Bulks List