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Description

The E3 ubiquitin ligase neural precursor cell-expressed developmentally downregulated gene 4 (NEDD4) controls the stability of TBK1 through K27-linked polyubiquitination

In patients requiring hydrochlorothiazide therapy and in whom hypokalemia cannot be risked, therapy may be initiated with 37.5 mg/25 mg of triamterene and hydrochlorothiazide