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Sertraline is an incredible gray area because there are some studies where they looked at models of what sertraline versus fluvoxamine do, and even though theyre both powerful regulators of the Sigma-1 receptor, in some endpoints that are thought to be Sigma-1 related, they do opposite things, and that might indicate that sertraline is actually a very powerful inhibitor of it

A prospective epidemiological study of acute mountain sickness in Nepalese pilgrims ascending to high altitude (4380 m)

In patients with coagulation-related phenotypes, anticoagulant or antiplatelet strategies may offer benefits, whereas those with dysautonomia or POTS may respond better to -blockers or volume-expanding agents

10.1016/j.freeradbiomed.2005.02.025 34 WangK.ChenX.-Z.WangY.-H.ChengX.-L.ZhaoY.ZhouL.-Y.et al (2022)