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32 Current research highlights the relevance of arterial elasticity/stiffness in vascular aging and cardiovascular diseases

Freshly resected human CRC specimens were dissected into 12-mm 3 fragments under sterile conditions

Elevated intracellular calcium levels, driven by ATP depletion, triggers chronic dehydration through activation of the KCa3.1 channel (i.e., the Gardos effect), promotes instability of critical cytoskeletal junctional complexes (e.g., spectrin-actin-tropomyosin, spectrin-actomyosin) through post-translational modifications on cytoskeletal adaptor proteins, and leads to activation of proteases (i.e