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The activation of the PI3 K/Akt/mTOR signalling pathway has been reported to play an active role in bone formation [83]

Protein therapeutic molecules, including antibodies (Schmitt and Greten, 2021), metabolism-blocking proteins (Liu et al., 2017), enzymes (Yu et al., 2024), and apoptosis-inducing agents (Hu and Kavanagh, 2003) have also been successfully combined with engineered bacteria for targeted therapy of tumors (Table 1)

The accumulation of ROS depends on a functional redox-homeostasis in the chloroplast and other cell compartments

The key mismatch driver is the constitutive hyperactivation of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway in tumor cells