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Conclusion Though not perfect, the no longer available Schillings test presented a useful option for judging the uptake of B12 and for clarifying whether an impaired uptake was caused by the lack of intrinsic factor

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The resulting elevated concentrations of homocysteine and MMA are often found in patients with low serum vitamin B 12 and can usually be lowered with successful vitamin B 12 replacement therapy

Deficiency In healthy adults, overt vitamin B 12 deficiency is uncommon, mainly because total body stores can exceed 2,500 g, daily turnover is slow, and dietary intake of only 2.4 g/day is sufficient to maintain adequate vitamin B 12 status (see The RDA) (4)