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Knezevic et al., 2021a), or by intragastric application of absolute alcohol (Gojkovic et al., 2021b) and intraperitoneal application of lithium overdose (Strbe et al., 2021)

NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

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