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Specifically, smart drug delivery systems (SDDSs) aim to enhance drug efficacy, minimize toxicity, and improve drug availability through precise administration at targeted sites 6 , utilizing both internal factors like redox potential, pH levels and external influences such as light, magnetic fields, and ultrasound 7,8,9,10,11

This leaky gut characteristic might be part of the low-grade chronic inflammation ( Faecalibacterium prausnitzii , and a rise in mucin-degrading species such as Akkermansia muciniphila ( Nevertheless, probiotics, prebiotics, and fecal microbiota transplantation (FMT) have been proposed microbiome-based treatments that have shown promise in preclinical models and early clinical studies ( Bacillus subtilis inhibits -synuclein aggregation and clears aggregates in an established Caenorhabditis elegans model of synucleinopathy

In these cells MYCN protein expression can be downregulated by ca

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