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The receptor for AGEs (RAGE), their principal binding partner, is abundantly expressed on cardiomyocytes, endothelial cells, and immune cells (Shen et al., 2020), triggering the release of pro-inflammatory cytokines such as IL-6, IL-1, and TNF- (Moldogazieva et al., 2019), which collectively contribute to myocardial injury and structural remodeling

Pregnancy and breastfeeding would be obvious contraindications given the lack of safety data

Het peptide kan de genexpressie benvloeden en een jeugdig fenotype bevorderen door herstellende processen in huidcellen te activeren en oxidatieve schade te verminderen