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The position of GSH in the model is supported by data showing that mutation of two of the arginines, R73 and R74, results in complete loss of substrate saturation with GSH (with CDNB as the electrophilic second substrate)

Cruciferous vegetables: Cruciferous vegetables such as broccoli and cauliflower provide sulforaphane, a phytochemical that reduces inflammation via the anti-inflammatory Nrf2 cellular signaling pathway

Secondly, through a transamination reaction, 3PHP receives an amino group from glutamate, producing 3-phosphoserine (3P-Ser) and -ketoglutarate (-KG), a step catalyzed by phosphoserine transaminase 1 (PSAT1)