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Many Nrf2 inducers including electrophilic agents such as dimethyl fumarate and natural products like sulforaphane, act on multiple cellular targets beyond Keap1, raising the possibility of off-target effects such as immunomodulation, altered drug metabolism or unintended transcription changes [130]

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Gong X., Li T., Wan R., Sha L

Both medications have potential long-term risks, such as hormonal imbalances with Sermorelin and gastrointestinal or cardiovascular issues with Semaglutide