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The framework is meant to help environmental regulatory agencies by providing examples of CECs monitoring programs and guiding the user through the process of identifying CECs key characteristics, how to communicate real and perceived risk from CECs to the public, and how laboratory analytical methods can be used in the identification process

We observed a consistent increase in sensitivity, or reduced IC 50 value, for mutant cells treated with doxycycline but not parental OVCAR5 cells, indicating that induction of mutant p53 sensitized cells to APR-246 (Fig