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The MAPK/ERK pathway facilitates regulatory influence on gene expression through recruitment of downstream transcription factorsit is known that melatonin can regulate the activity of the cJun Nterminal kinases (JNKs) and the transcription factor cJun in traumatically injured mouse brains (Rehman et al., 2019), and possibly in breast cancer cells ( Drosophila melanogaster (MacDonald et al., 2013), autophagy and cell death through the regulation of pro and antiapoptotic proteins Bcl2 associated Xprotein (Bax), Bcell lymphoma 2 (Bcl2) (Fazal et al., 2017) and suggested to have both beneficial (Fontana et al., 2012