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Nature 597(7874):9296

Bethesda, Md 15 (8), 100273

Yang and Stockwell 2016)

[37] observed that methotrexate (MTX), a chemotherapy drug known for its severe cardiac side effects, induced alterations in the cardiac histopathology and enhanced the caspase-3 expression in the rat cardiac tissues, indicating the exacerbation of cardiomyocyte apoptosis