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Disclosures: Madelyn Subocz: Nothing to Disclose, Zachary Fricker: Lipocine, Inc: Grant/Research Support, Pick Research: Consultant, River2Renal Corp: Grant/Research Support, Bausch, Inc.: Grant/Research Support 2289 INCREASED RISK OF CLOSTRIOIDES DIFFICILE INFECTION IN PATIENTS WITH CIRRHOSIS ON SECONDARY PROPHYLAXIS FOR SPONTANEOUS BACTERIAL PERITONITIS: A RETROSPECTIVE MATCHED COHORT STUDY Vinay Jahagirdar 1 Waqas Rasheed 2 Hanna Blaney 3 Hassam Ali 4 Jasmohan Bajaj 5 , 1 University of Missouri Kansas City School of Medicine, 2 University of Kentucky, 3 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4 East Carolina University, 5 Virginia Commonwealth University Background: Patients with a prior episode of spontaneous bacterial peritonitis (SBP) are at very high risk of recurrence