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Tumor cells also release damage-associated molecular patterns (DAMPs) after IR, including high-mobility group box 1 (HMGB1), heat shock proteins (HSPs), and calreticulin (CRT), which mediate phagocytosis of antigen-presenting cells (APCs) and initiate tumor-specific T cell activation

CJC-1295 + Ipa elevates endogenous GH, which drives upstream IGF-1 production

Challenges and Future Directions of Nasal-Brain Delivery Despite the significant promise of nasal nano-delivery systems for CNS disease treatment, their clinical translation remains constrained by a series of complex and challenges, including concerns over long-term biological safety, difficulties in scalable and reproducible manufacturing, and the absence of clear regulatory frameworks for approval

All patients were treated with methimazole for 12 weeks to achieve euthyroidism