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However, excessive NO scavenging in conditions of elevated Hb concentrations in the MEJs can reduce NO bioavailability and induce endothelial dysfunction (Denton et al., 2021), increasing vascular resistance (Straub et al., 2014a)

The carrier-linked prodrug of 87

The PPP occurs in the cytoplasm, where glucose-6-phosphate dehydrogenase (G6PD) catalyzes the conversion of G6P to ribose-5-phosphate, a precursor for nucleotide/nucleic acid synthesis (Hay, 2016