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Among the various natural products, ubiquitous hydroxylated flavonoids have been documented as a potent inhibitor of tyrosinase due to their structural similarities with tyrosinase substrates, such as l-tyrosine and l-DOPA, and substantial antioxidant properties 11,29,30,31

Protein thiols are also significant targets of reactive oxygen species in vivo

Although the mechanisms remain uncertain, it is hypothesized that the term HPA axis is more susceptible to glucocorticoid-mediated downregulation of central GR expression, leading to impaired negative feedback regulation

Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intra-tumoral immune signature benefit from pembrolizumab: results from a single-arm phase 2 trial