bacterial and host-derived glutathione are required to activate prfa Multiple regulatory check-points control expression protein Glutathione activates virulence gene expression

Glutathione activates virulence gene expression of an intracellular pathogen Nature RCSB PDB 5LRS: The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with glutathione and a 30 bp operator PrfA box motif Diverse roles of low molecular weight thiol GSH in Francisella's virulence, location sensing and GSH stealing from host ScienceDirect PrfA, the master virulence regulator of Listeria monocytogenes: structuralfunctional insights, regulatory architecture, and antivirulence strategies Molecular Biology Reports Springer Nature Link

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