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Oxidative stress can induce the misfolding and oligomerization of alpha-synuclein, contributing to its accumulation and the formation of toxic aggregates [162]

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As mentioned, no other medical intervention except for drug cessation and liver function monitoring has been made in the most cases of antithyroid drugs-induced hepatotoxicity.8,27,98 However, intra vascular glutathione was founded to be an effective treatment in a case of methimazole-induced hepatotoxicity and lowered transaminase levels in the patient.99 As mentioned, glutathione (GSH) has been proven to play a critical role in preventing methimazole-induced hepatic injury in different experimental models.41,51,52 Hence, using glutathione in patients with methimazole-induced liver injury seems to be a reasonable choice

AMERICAS GLUTATHIONE MARKET SIZE, BY INJECTABLE, 2018-2032 (USD MILLION) TABLE 216