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Nrf2 is generally coupled to Kelch-like ECH-associated protein 1 (Keap1) in an inactive form, and the ubiquitin-proteasome system destroys the complex, allowing cells to maintain a steady low level of Nrf2 (258)

The analyzed species were hens, broilers, rabbits, mice, carps, turbots, Lateolabrax maculatus , chicks, sheep, and rats

To date, it has been observed that the treatment with this kind of antitumor agents causes ROS generation, mitochondrial dysfunction (including frataxin deficiency, mitochondrial DNA damage and defective components of ETC), loss in antioxidant enzymes, ion channels disturbances and nerve tissue damage (protein carbonylation and lipid peroxidation) (Areti et al., 2014

Wu G, Lu ZH, Kulkarni N, Ledeen RW (2012) Deficiency of ganglioside GM1 correlates with Parkinsons disease in mice and humans