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In mice, 3-AR receptors mediate cold-induced thermogenesis (223) and pharmacological activation of 3-ARs acutely stimulate lipolysis leading to two-fold increase in energy expenditure, a dramatic ten-fold increase in insulin levels, and 4050% reduction in food intake (98)

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Treated animals show increased oxygen consumption and energy expenditure measured by indirect calorimetry, confirming enhanced metabolic rate

Supplementation of these vitamins to the diet in therapeutic doses helps to balance any existing deficiencies, thus ensuring the production of the required amount of coenzymes