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Haghighat N, Rajabi S, Mohammadshahi M

They are known to be involved in the pathogenesis of chronic conditions associated with VC

A recent study also showed that reduced GH signaling in the liver of Snell mice upregulates the CMA (Endicott et al., 2020)

The SOD absence accompanied with the swells of mitochondrial structure and mitochondrial cristae changes, further decreased ATP production and elevated level of oxidative DNA damage can be observed which eventually impact the RPE function