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Description

Briefly, mice with a floxed allele of exon 5 Ppara were built up by using homologous recombination in ES cells and back-crossed with transgenic mice expressing Cre recombinase regulated by the albumin (Alb-Cre) promoters for at least eight generations to create hepatocyte-specific ( Ppara Hep ) knockout mice

doi: 10.3390/ijms25115874 159

NMN-treated mice also maintained higher levels of food and water consumption compared to control mice, which suggested that NMN did not cause severe side effects, such as growth defect and loss of appetite (Mills et al., 2016)