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Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohns disease

Clinical Trials Requires FDA IND (Investigational New Drug) application IRB (Institutional Review Board) oversight Strict protocols and monitoring This is RESEARCH, not treatment 2

MET activation is thus involved in brain plasticity, as suggested by the fact that HGF administration on hippocampal slices enhances the phosphorylation of the glutamatergic NMDA receptor subunit GluN1, augments the NMDA-mediated currents, and increases the amplitude of long-term potentiation (LTP) induced by elevated neuronal activity (Akimoto et al., 2004)