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Pro-oxidants Pro-oxidants and Antioxidants, Defined What is Oxidation

TGF- in turn activates Smad2/3 signaling inducing fibroblast proliferation, differentiation into myofibroblasts, and the production of ECM components such as fibrillar collagen, fibronectin, and proteoglycans (168, 171)

This work has culminated in the synthesis of a small molecule AT 4 receptor agonist capable of penetrating the blood-brain barrier and facilitating cognitive processing presumably by increasing synaptogenesis (133)