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Role of NF-B and Akt/GSK3 pathways in the regulation of the expression and activity of CBS The compounds identified in our screening also confirm the importance not only of the Akt/GSK3 pathway but also of NF-B, which is often activated by Akt/GSK3 (Ozes et al., 1999), in the regulation of CBS activity and expression

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Impaired glutathionerelated antioxidant defenses in the arterial tissue of diabetic patients

Fetal body and organ weights were obtained

[4] The earliest clinical trial involving senolytics was a two-center open-label pilot study (NCT02874989) involved a cohort of 14 patients diagnosed with idiopathic pulmonary fibrosis (IPF)