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Gradual reduction in dullness, improved skin clarity, better tone uniformity and enhanced natural glow are commonly noticed as internal antioxidant balance improves.

It is also possible for future studies to investigate the efficacy and safety of using botanical drugs and conventional pharmacological agents in combination, which may allow the dose of the pharmacological agents to be reduced, subsequently reducing the adverse effects experienced by the patients

TCM formulas in the treatment of BC Xiaoyao San is first mentioned in the Tai Ping Hui Min He Ji Ju Fang (formulas of the Bureau of the Taiping Huimin Pharmacy) in ancient China (960 A.D.-1279 A.D.) with the function of soothing liver, relieving depression, fortifying spleen, and nourishing the blood