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Future advances will depend on innovative drug delivery systems and integration with complementary proteostasis-modulating strategies

8,9 Furthermore, smokers inhale 1 g of iron per 25 cigarettes and the smoke itself releases iron from ferritin, giving the lung surface fluid ample iron to generate the toxic hydroxyl radical through the Haber-Weiss and Fenton reactions

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DDS innovationsthrough pharmacokinetic optimization, precision targeting, and combinatorial strategiesrepresent transformative solutions to overcome these barriers, offering safer, more effective therapeutic options for complex clinical scenarios