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For a peripheral indication such as DPN, delivery strategies should be assessed against a clear target rationale (peripheral nerve/DRG versus central pain processing) and should demonstrate PF-specific improvements in exposure aligned with disease-relevant outcomes beyond pain behavior (e.g., nerve conduction, intraepidermal nerve fiber density, and myelin/axon integrity)

Shevach, Jonathan M

1 Ferrostatin-1s RTA capacity was later attributed to the amine group and necessary N-cyclohexyl moiety that enabled anchoring in lipid membranes

A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes