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The prevalence of fatigue in cirrhosis exhibits considerable variability across studies, populations, and etiologies, with the definitive prevalence of this condition remain uncertain

Its unique ability to cross the blood-brain barrier allows it to positively influence neurotransmitter activity, supporting memory, learning, and overall mental clarity

Patients may present either shortly after birth with acute deterioration, metabolic acidosis, and hyperammonemia or later at any age with diverse clinical manifestations