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It can cause some local side effects (irritation, itching) and must be used long-term to maintain its effectiveness

Declarations Acknowledgement The authors acknowledge DST-FIST for sponsoring the Department of Biotechnology, Central University of Tamil Nadu

However, their unsatisfactory therapeutic efficacy due to poor skin penetration, transient therapeutic effects, and risks of cutaneous atrophy or tachyphylaxis with prolonged use has constrained their clinical applications [3, 4]

Tendon fibroblast studies have additionally documented BPC-157 upregulation of growth hormone receptor (GHR) expression, a receptor that signals canonically through the JAK2-STAT pathway [2]