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Peer review Peer review information Nature Chemical Biology thanks the anonymous reviewers for their contribution to the peer review of this work

Thiosulfate sulfurtransferase (rhodanese or TST) is also known as a sulfurtransferase in mitochondria which produces sulfane sulfur although biological activity of this enzyme remains poorly understood [23]

11 PKD is characterized by a high prevalence of iron overload regardless of whether patients require regular transfusions, necessitating monitoring in all patients and frequent institution of iron chelation therapy

Cells were treated with the appropriate dose of APR-246 24 hours after seeding