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Irreversible Inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

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This is of particular interest when the target protein lacks classical druggable pocketsi , in which V d and V a represent the volumes of the donor and the acceptor wells, respectively, A is the surface of the artificial membrane, t is the permeation time, whilst d a and d eq are the absorbance measured in the acceptor well and the theoretical equilibrium absorbance value, respectively