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In addition, different antioxidants simultaneously exhibit multiple therapeutic attributes that aid in brain tumor management by promoting radiosensitization, potentiating the effect of chemotherapeutic agents as adjuvants, and reversing chemoresistance [58,59,60]

MRD cells were also generated in vivo, by treating mouse xenografts of the 105K Tsc2 / RCC line in syngeneic C57BL/6J mice with rapamycin (3 mg/kg, intraperitoneally [IP] 3 times/wk for 1 month, MRD525), or the bi-steric inhibitor RMC-6272 (8 mg/kg, IP once/wk for 1 month, MRD639), followed by 2 months of treatment cessation (Figure 1A)

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