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This antitumor effect could be reversed by aspartate supplementation [26], reinforcing that the presence of other metabolites (in this case, another amino acid) in the TME can influence the effects of a single one in tumor biology

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Chemical structure of MRTX849 Concluding remarks In summary, a comprehensive assessment of both non-enzymatic and enzymatic binding of compounds to GSH can simultaneously investigate the electrophilicity and metabolism of covalent inhibitors, offering better insights into compound properties

doi: 10.3390/ph15080931