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Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers (24, 25)

Nevertheless, interindividual response variability, high cost, and adherence challenges may limit widespread clinical implementation

They are involved in regulating brain development, neuron regeneration, pathogen elimination, and brain cleaning, which includes synapse pruning, elimination of dead and superfluous cells, as well as removal of various molecule aggregates and potentially dangerous antigens (7981)

There is now a huge literature on the ascorbateglutathione cycle, including new and important findings that add context and complexity to cycle functions